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Chanca Piedra 500 mg 90 vegi caps
Chanca Piedra 500 mg 90 vegi caps Quantity in Basket: None
Code: AOR-CP90


Price: $19.97

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Chanca Piedra from AOR
 
Supports the Liver and Kidneys*
Dosage: 500 mg
Size: 90 vegi-caps
Category:
  Product Number: 08017
Product Code: AOR-CP90

Chanca Piedra is the Spanish common name for Phyllanthus nirui, a small shrub, and literally means "break stone." The botanical is traditionally used to support the health of the kidneys, liver and gall bladder. It is mainly utilized as a liver protective and to treat gall and kidney stones. It also has anti-viral properties.

Product Discussion from AOR:

Phyllanthus amanes (PA)
PA is a perennial herb common in hot central and southern areas of the Indian Subcontinent.

Chemistry
The extract of the leaves contains various alkaloids, lignans, flavonoids and triterpenes, including phyllanthin and hypophyilanthis as well as ellagic acid. Traditionally, the plant has been used as a stomachic, diuretic, ferbifuge, antiseptic, and as a remedy for diarrhea. In addition, PA has been used to provide support for urogenital conditions.

Pharmacological effects
PA has been reported to exhibit marked antihepatitis B virus surface antigen activity in in-vivo (Thyagarajan etal (1998), 1490 a, b; Shead, et-al, 1992) and in-vitro studies (Blumburg, 1991). Infectitious hepatitis is due to the inability of the bodies immune system to eliminate the virus from the liver cells: hence the “carrier state”. An infection with the virus is documented by detectable levels of various viral antigens in the blood, including HBaAg (the surface antigen of the virus) as well as antibodies to the core of virus (HBc antibodies). In one study, 37 patients with chronic viral hepatitis B were treated with a daily dose of 600mg of PA for 30 days. 59% of the patients lost the HBsAg two weeks after the end of the treatment. Furthermore, none of the cases followed for up to 9 months had any symptoms of HBsAg. The authors postulated that PA may inhibit proliferation of the virus by inhibiting replication of the genetic material of the virus.

In another clinical trial involving 160 children (age 1-12 years) with infective hepatitis, the authors reported “cures” in 101 children with 59 dropouts. Normal appetite was seen in 7 days, while jaundice, hepatic tenderness, and other clinical features all disappeared completely within 5 weeks.

 

Gallstones / Kidney stones
It is reported that over 600, 000 patients are treated for gallstones in the U.S. alone for each year. In South America, PA is commonly known as “Chanca Piedre” which in the local dialect of Spanish means, “to break stone”. PA has been used to eliminate gall bladder and kidney stones. In addition, PA has been used to treat gall bladder infections In South America, and is often taken in the form of tea. PA has been used in Germany and France to treat gall bladder and kidney stones with over a 95% success rate within 1-2 weeks of treatment. In France, Brazilian researchers have postulated that phyllanthin has powerful spasmolytic activity, which is probably the mechanism by which stones are expelled.

References
i. Freitas AM, Schor N, Boim MA. “The effect of Phyllanthus niruri on urinary inhibitors of calcium oxalate crystallization and other factors associated with renal stone formation.” BJU Int 2002 Jun; 89(9): 829-34.
ii. Campos AH, Schor N. “Phyllanthus niruri inhibits calcium oxalate endocytosis by renal tubular cells: its role in urolithiasis.” Nephron 1999; 81(4): 393-7.
iii. Ogata T, Higuchi H, Mochida S, Matsumoto H, Kato A, Endo T, Kaji A, Kaji H. “HIV-1 reverse transcriptase inhibitor from Phyllanthus niruri.” AIDS Res Hum Retroviruses 1992 Nov; 8(11): 1937-44.                                                             iv. Campos AH, Schor N. “Phyllanthus niruri inhibits calcium oxalate endocytosis by renal tubular cells: its role in urolithiasis.” Nephron 1999; 81(4): 393-7.
v. Mehrotra R, Rawat S, Kulshreshtha DK, Patnaik GK, Dhawan BN. “In vitro studies on the effect of certain natural products against hepatitis B virus.” Indian J Med Res 1990 Apr; 92: 133-8.
vi. Syamasundar KV, Singh B, Thakur RS, Husain A, Kiso Y, Hikino H. “Antihepatotoxic principles of Phyllanthus niruri herbs.” J Ethnopharmacol 1985 Sep; 14(1): 41-4.

 

See below for additional product discussion.

 

 

 

Phytochemicals from Phyllanthus niruri Linn. and their pharmacological properties: a review.

J Pharm Pharmacol. 2006 Dec;58(12):1559-70.

Bagalkotkar G, Sagineedu SR, Saad MS, Stanslas J.

This review discusses the medicinal plant Phyllanthus niruri Linn. (Euphorbiaceae), its wide variety of phytochemicals and their pharmacological properties. The active phytochemicals, flavonoids, alkaloids, terpenoids, lignans, polyphenols, tannins, coumarins and saponins, have been identified from various parts of P. niruri. Extracts of this herb have been proven to have therapeutic effects in many clinical studies. Some of the most intriguing therapeutic properties include anti-hepatotoxic, anti-lithic, anti-hypertensive, anti-HIV and anti-hepatitis B. Therefore, studies relating to chemical characteristics and structural properties of the bioactive phytochemicals found in P. niruri are very useful for further research on this plant as many of the phytochemicals have shown preclinical therapeutic efficacies for a wide range of human diseases, including HIV/AIDS and hepatitis B.

 

Lipid lowering activity of Phyllanthus niruri in hyperlipemic rats.

J Ethnopharmacol. 2002 Sep;82(1):19-22.

Khanna AK, Rizvi F, Chander R.

 

The lipid lowering activity (LLA) of Phyllanthus niruri has been studied in triton and cholesterol fed hyperlipemic rats. Serum lipids were lowered by P. niruri extract orally fed (250 mg/kg b.w.) to the triton WR-1339 induced hyperlipemic rats. Chronic feeding of this drugs (100 mg/kg b.w.) in animals simultaneously fed with cholesterol (25 mg/kg b.w.) for 30 days caused lowering in the lipids and apoprotein levels of VLDL and LDL in experimental animals. The LLA of this drug is mediated through inhibition of hepatic cholesterol biosynthesis, increased faecal bile acids excretion and enhanced plasma lecithin: cholesterol acyltransferase activity.

 

Phyllanthus niruri normalizes elevated urinary calcium levels in calcium stone forming (CSF) patients.

Urol Res. 2004 Oct;32(5):362-6. Epub 2004 Jun 19.

Nishiura JL, Campos AH, Boim MA, Heilberg IP, Schor N.

Phyllanthus niruri is a plant used for years in Brazil to treat urinary calculi. We prospectively evaluated the effect of P. niruri intake on 24 h urinary biochemical parameters in an attempt to assess its in vivo effect in calcium stone forming (CSF) patients. A total of 69 CSF patients (39 males and 30 females, 38+/-8 years old) were randomized to take either P. niruri ( n=33) (450 mg capsules, td) or placebo ( n=36) for 3 months. Blood calcium, uric acid, citrate, magnesium, oxalate, sodium and potassium were determined at baseline and at the end of the study. A subset analysis was made in patients classified according to the presence of metabolic abnormalities (hypercalciuria, hyperuricosuria, hyperoxaluria, hypocitraturia and hypomagnesiuria). Overall, there were no significant differences in the mean values of urinary parameters between the urine samples before and after P. niruri intake, except for a slight reduction in mean urinary magnesium after P. niruri, which was within the normal range. However, in the subset analysis, we observed that P. niruri induced a significant reduction in the mean urinary calcium in hypercalciuric patients (4.8+/-1.0 vs 3.4+/-1.1 mg/kg/24 h, P<0.05). In this short-term follow-up, no significant differences in calculi voiding and/or pain relief between the groups taking P. niruri or the placebo were detected. Our data suggest that P. niruri intake reduces urinary calcium based on the analysis of a subset of patients presenting with hypercalciuria. Larger trials including primary hypercalciuric stone formers should be performed in order to confirm these findings and to determine the possible clinical consequences of urinary calcium reduction during P. niruri administration.

 

Antihepatotoxic principles of Phyllanthus niruri herbs.
J Ethnopharmacol 1985 Sep; 14(1): 41-4.
Syamasundar KV, Singh B, Thakur RS, Husain A, Kiso Y, Hikino H.                                        

Among phyllanthin, hypophyllanthin, triacontanal and tricontanol isolated from a hexane extract of Phyllanthus niruri, phyllanthin and hypophyllanthin protected against carbon tetrachloride- and galactosamine-induced cytotoxicity in primary cultured rat hepatocytes, while triacontanal was protective only against galactosamine-induced toxicity.

 

In vitro studies on the effect of certain natural products against hepatitis B virus.
Indian J Med Res 1990 Apr; 92: 133-8.
Mehrotra R, Rawat S, Kulshreshtha DK, Patnaik GK, Dhawan BN.

Picroliv (active principle from Picrorrhiza kurroa), its major components picroside I, catalpol, kutkoside I, kutkoside, andrographolide (active constituent of Andrographis paniculata), silymarin and Phyllanthus niruri extract were tested for the presence of anti hepatitis B virus surface antigen (anti HBs) like activity. HBsAg positive serum samples obtained from hepatitis B virus (HBV) associated acute and chronic liver diseases and healthy HbsAg carriers were used to evaluate the anti-HBs like activity of compounds/extract. The latter were mixed with serum samples and incubated at 37 degrees C overnight followed by HBsAg screening in the Elisa system. A promising anti-HBsAg like activity was noted in picroliv (and its major components) catalpol, P. niruri, which differed from the classical viral neutralization. Picroliv also inhibited purified HBV antigens (HBsAg and HBsAg) prepared from healthy HBsAg carriers. The in vitro testing system appears to be a suitable model to identify an agent active against HBV, prior to undertaking detailed studies.

 

HIV-1 reverse transcriptase inhibitor from Phyllanthus niruri.
AIDS Res Hum Retroviruses 1992 Nov; 8(11): 1937-44.
Ogata T, Higuchi H, Mochida S, Matsumoto H, Kato A, Endo T, Kaji A, Kaji H.

 

An aqueous extract of Phyllanthus niruri (Euphorbiaceae) inhibited human immunodeficiency virus type-1 reverse transcriptase (HIV-1-RT). The inhibitor against HIV-1-RT in this plant was purified by combination of three column chromatographies, Sephadex LH-20, cellulose, and reverse-phase high-performance liquid chromatography. The inhibitor was then identified by nuclear magnetic resonance (NMR) spectra as repandusinic acid A monosodium salt (RA) which was originally isolated from Mallotus repandus. The 50% inhibitory doses (ID50) of RA on HIV-1-RT and DNA polymerase alpha (from HeLa cells) were 0.05 microM and 0.6 microM, respectively, representing approximately a 10-fold more sensitivity of HIV-1-RT compared with DNA polymerase alpha. RA was shown to be a competitive inhibitor with respect to the template-primer while it was a noncompetitive inhibitor with respect to the substrate. RA as low as 10.1 microM inhibited HIV-1-induced cytopathogenicity in MT-4 cells. In addition, 4.5 microM of RA inhibited HIV-1-induced giant cell formation of SUP-T1 approximately 50%. RA (2.5 microM) inhibited up to 90% of HIV-1 specific p24 antigen production in a Clone H9 cell system.

 

 

 

Suggested Usage: Take one capsule three times a day, or as directed by a qualified health practitioner. May be take as a tea by emptying contents into warm water.

Other Label Information: . Do not take if pregnant or nursing. Keep out of reach of children. 
 

SUPPLEMENT FACTS
Serving Size: 1 capsule
 
  Amount  % DV

Phyllanthus niruri 10:1 plant extract (3% Bitter Principles) 500 mg *

Other ingredients: May contain microcrystalline cellulose.
*Daily Value not established

Contains no known allergen. AOR guarantees that no ingredients not listed on the label have been added to the product.

Capsule: Vegetarian.(hydroxypropylmethylcellulose, gellan gum, water and potassium acetate).
 
These statements have not been evaluated by the food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.