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Ortho Glucose II 90 vegi-caps
Ortho Glucose II 90 vegi-caps Quantity in Basket: None
Code: AOR-ORGL


Price: $25.74

Quantity:  

Ortho Glucose II™ from AOR™ Advanced Orthomolecular Research
Supports Adaptive Homeostasis — Adaptogenic Botanicals & Nutrients*
Dosage: 3 Capsules
Size: 90 Capsules
Category: AOR
Product Number: 08190
Product Code: AOR-ORGL

Ortho Glucose II™ is AOR´s most advanced glucose metabolism support formula. Micronutrients at the forefront of glucose metabolism technology have been included in this formulation, which was designed to maximize insulin sensitivity and to protect against the inefficient metabolism of glucose associated with such metabolic disorders as Syndrome X and Type II Diabetes.

Includes micronutrients that help to support glucose metabolism and insulin sensitivity:
Diabetes is a syndrome characterized by abnormally elevated sugar levels in the blood. There are two types of diabetes mellitus: type 1 or insulin-dependent diabetes and type 2, which is non-insulin-dependent. Insulin is central to diabetes simply because it is the hormone that regulates the metabolism of glucose. Insulin regulates the entry of glucose in our cells, thereby regulating blood sugar levels. The ß cells of the pancreas produce insulin. Insulin is released when blood glucose levels rise, as is the case after a meal. Glucose is the main source of energy for our cells and without the action of insulin, there is improper glucose utilization and storage, which leads to several metabolic derangements including elevated blood sugar levels.

The incidence of diabetes is rapidly increasing and in 2005, 7% of the United States population had diabetes. The prevalence of the disease increases with age.

In type 1 diabetes, the immune system is attacking the pancreas's insulin-producing cells. This leads to the inability to produce adequate levels of insulin and without the presence of insulin, blood sugar levels rise uncontrollably. Type 1 diabetes sufferers require additional insulin to regulate their blood glucose levels. Type 1 diabetes is typically diagnosed in childhood or early adulthood. Unfortunately, the cause remains unclear.

Type 2 diabetes usually develops in late adulthood and although insulin production may be compromised later in the course of type 2 diabetes, the condition is primarily the result of increased insulin resistance. Insulin resistance refers to the inability of our cells to respond to insulin even when normal levels of insulin are present. Once cells become insulin resistant, glucose cannot enter cells and blood glucose levels rise. Type 2 diabetes is far more common, comprising 90% of diabetic patients.

Type 2 diabetes is a disease that develops slowly and for which three separate stages have been identified:

Insulin resistance has another serious consequence; not only does it lead to elevated blood sugar levels but it also predisposes to heart disease. Diabetics are twice as likely to suffer from cardiovascular disease and are five times more likely to experience a heart attack. Insulin resistance gives rise to risk factors for heart disease such as lower HDL cholesterol levels (the beneficial cholesterol fraction), abdominal obesity, higher triglyceride levels and elevated low-density cholesterol (the unfavourable cholesterol fraction). Obesity is closely related to insulin resistance and is one of the main risk factors for the development of type 2 diabetes. There is also a strong genetic influence on the development of type 2 diabetes with identical twins (which share the same genes) having a 90% concordance in the occurrence of the disease.

Other frequent complications of diabetes include retinal damage, blindness (diabetes causes 8% of blindness cases in the US), hypertension (73% of diabetics have elevated blood pressure), neuropathy (affecting 60-70% of diabetics), arteriosclerosis, dental disease, increased susceptibility to infections, stroke, kidney failure (main cause of dialysis in developed countries) and ulcer formation, which can lead to gangrene and amputation (one amputation every 30 seconds worldwide). In type 2 diabetes, especially earlier in the disease process, exercise, dietary changes and weight loss may restore insulin sensitivity and normalize blood sugar levels. Patients that control their blood sugar levels minimize the damage to their organs (mainly kidneys, blood vessels and eyes) and their incidence of complications is significantly reduced and nearly normal.

AOR™ guarantees that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, dairy, soy, eggs, fish or shellfish.

Suggested Use:
Take 1 capsule three times daily, half an hour before a meal, or as directed by a qualified health care practitioner.

Main Applications:
• Increases insulin sensitivity
• Supports normal blood sugar balance

Source:
Multi-Source

Pregnancy / Nursing:
No Studies; best to avoid.

Cautions:
Persons using insulin and other diabetic medications should only use this supplement under physician supervision.

Note: Herbal extracts will naturally vary in color from one crop to another.

Supplement Facts:
Serving Size: 3 capsules
Servings per Container: 30
Amt. per 3 Capsules % RDI
Chromium (trivalent Cr picolinate) 501 mcg 418%
Cinnamon Extract

100 mg

*
Gymnemma Sylvestre Extract 399 mg *
Bitter Melon Extract (Momordica Charantia) 255 mg *
R(+)-Lipoic Acid 300 mg *
% RDI Age 12 and above
* Need for human nutrition not established
Other Ingredients: Capsule: hypromellose, water.

Several well-researched nutrients have demonstrated that they can encourage healthy glucose metabolism. Ortho Glucose™ is a nutritional formula that contains nutrients capable of supporting the action of insulin and that encourage healthy glucose metabolism:

Ortho Glucose II™ contains, chromium picolinate, bitter melon extract , corosolic acid, gymnema sylvestre, cinnamon extract, and R(+)- lipoic acid. These nutrients and plant extracts are supported by clinical research in diabetic subjects. They have been shown to help reduce elevations in blood sugar levels, potentiate the action of insulin, improve the cellular utilization of glucose and reduce risk factors for complications associated with diabetes. They are the ideal choice for those trying to regain normal carbohydrate metabolism and striving to achieve normal blood glucose levels

Cinnamon:

Cinnamon is a popular spice that has been known since antiquity. It is no coincidence that cinnamon is often used for the preparation of desserts. Indeed, laboratory work has demonstrated that cinnamon enhances cellular glucose uptake and utilization. Animal studies have also confirmed that supplementation with cinnamon improves the action of insulin, increases insulin levels and prevents the development of insulin resistance in animals fed a diet high in sugar.

Clinical trials have revealed that the bark of this small tree is a great choice for patients suffering from type 2 diabetes mellitus. Cinnamon improves the cellular uptake of glucose through its insulin-like activity. It also appears to reduce the gastric emptying rate, which results in lower levels of blood glucose after eating. Reported reduction of fasting plasma glucose levels varied from 10 to 29% depending on the initial glucose levels, and patients with poorly controlled blood glucose levels benefited even more from supplementation with cinnamon.

Diabetic patients often have abnormal blood lipid and cholesterol levels, which predisposes them to cardiac complications. After 40 days of cinnamon supplementation, blood triglycerides and cholesterol levels were significantly reduced. Cinnamon can therefore be used to avoid type 2 diabetes, decrease blood glucose levels in diabetics and reduce the risks of common complications associated with diabetes.

Chromium:

Chromium is an essential mineral for the metabolism of carbohydrates. Chromium increases the sensitivity of insulin receptors, which increases the cellular transport of glucose and reduces blood sugar levels. Double-blinded, placebo-controlled studies have demonstrated that chromium supplementation lowers blood glucose levels, reduces hemoglobin A1c concentrations, and improves cholesterol levels.

Momordica Charantia:

Momordica charantia, or MC (commonly known as bitter melon), is a fruit from the Cucurbitaceae family that is found in tropical areas throughout the world. It has been known as a 'healing food' in traditional circles, and in modern scientific ones the fruit extract has been studied for its potential with respect to a number of clinical applications, including microbial infections, cytotoxicity for certain types of cancer - and most notably - diabetes.

The MC plant is exceptionally dense with micronutrients: the ones that are attributable to its hypoglycemic effects are charantin, cucurbutanoids, momordicin, oleanolic acids, and insulin-like peptide (plant (p)-insulin), the latter being structurally similar to bovine insulin; other micronutrients found in MC include vitamins A and C and beta-carotene, as well as iron, phosphorus, and potassium.

Scientists have determined that the mechanism of action for MC extract's ability to reduce blood sugar levels by increasing glucose utilization by the liver, inhibiting gluconeogenesis (glucose production from non-carbohydrate sources), and improving glucose oxidation. MC extract has been clinically tested with both type I and type II diabetes, and in the latter, blood sugar reductions of as much as 54% have been observed after 3 weeks of MC extract supplementation.

Gymnema Sylvestre:

Gymnema sylvestre (GS) is an herb belonging to the Asclepiadacea family with an established history of use within the Ayurvedic tradition of medicine in India. The hypoglycemic effect of this herb was scientifically tested for the first time in 1930. Further studies revealed that GS significantly lowered blood glucose levels in both insulin-dependent and non-insulin-dependent diabetic rats. In human clinical trials, GS extracts were effective in patients with type 1 and type 2 diabetes. In 22 type 2 diabetes patients, GS extract resulted in a significant reduction in blood glucose, and in sugar-modified haemoglobin and plasma proteins. 5 of the 22 patients were able to discontinue their standard medications and maintain healthy blood glucose levels with GS alone. Similar results were found in a study of 27 type 1 diabetes patients. The GS, along with its other effects, reduced the requirements for insulin and brought serum lipids to almost normal levels. The GS extract appeared to enhance the body's own insulin, possibly by regenerating or repairing beta cells which produce insulin.

R(+)- LIPOIC ACID:

Lipoic acid, particularly in the form of alpha-lipoic acid, is primarily an exceptionally versatile antioxidant which also exerts an effective glucose-metabolizing action. The latter has been demonstrated in numerous trials, including one randomized, double-blind, placebo-controlled study where 60 Type II diabetics were given at least 600 mg of alpha-lipoic acid daily and subsequently reported a 27% improvement in insulin-stimulated glucose disposal over their placebo-receiving counterparts. It is important to note that this study used alpha-lipoic acid, which is 50% comprised of the inert S(-)- enantiomer, with the effective R(+)-enantiomer making up the remainder.

COROSOLIC ACID:

The leaves of the banaba plant (Lagerstroemia speciosa) yield an extract known as corosolic acid that has been shown in clinical studies to reduce blood glucose levels between 20-30% in Type II diabetics.

References:

Mang B, Wolters M, Schmitt B, Kelb K, Lichtinghagen R, Stichtenoth DO, Hahn A. Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2. Eur J Clin Invest. 2006 May;36(5):340-4.

Hlebowicz J, Darwich G, Bjorgell O and Almer LO. Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects. Amercian Journal of Clinical Nutrition. 2007; 85(6):1552-1556.

Judy WV, Hari SP, Stogsdill WW, Judy JS, Naguib YM, Passwater R. Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A dose-dependence study. J Ethnopharmacol. 2003 Jul;87(1):115-7.

Alpha-lipoic acid. Monograph. Altern Med Rev. 2006 Sep;11(3):232-7.

Yuen VG, Orvig C, McNeill JH. Comparison of the glucose-lowering properties of vanadyl sulfate and bis(maltolato)oxovanadium(IV) following acute and chronic administration. Can J Physiol Pharmacol. 1995 Jan;73(1):55-64.

Cohen N, Halberstam M, Shlimovich P, Chang CJ, Shamoon H, Rossetti L. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. J Clin Invest. 1995 Jun;95(6):2501-9.

Momordica charantia (bitter melon). Monograph. Altern Med Rev. 2007 Dec;12(4):360-3.

Cesarone MR, Belcaro G, Rohdewald P, Pellegrini L, Ledda A, Vinciguerra G, Ricci A, Gizzi G, Ippolito E, Fano F, Dugall M, Cipollone G, Acerbi G, Cacchio M, Del Boccio G, Di Renzo A, Stuard S, Corsi M. Improvement of diabetic microangiopathy with pycnogenol: A prospective, controlled study. Angiology. 2006 Aug-Sep;57(4):431-6.

Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharmacol. 1990 Oct; 30(3): 295-300.

Shanmugasundaram ER, Rajeswari G, Baskaran K, Rajesh Kumar BR, Radha Shanmugasundaram K, Kizar Ahmath B. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharmacol. 1990 Oct; 30(3): 281-94.


The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide medical advice to individuals. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes. Any reproduction in whole or part and in print or electronic form without express permission is strictly forbidden. Permission to reproduce selected material may be granted by contacting AOR Inc.

Copyright © 2005, Advanced Orthomolecular Research

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.