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R(+) Lipoic Acid - 150 mg 90 vegi-caps - AOR (08005)
R(+) Lipoic Acid - 150 mg 90 vegi-caps -  AOR (08005) Quantity in Basket: None
Code: AOR-RLIP


Price: $39.97

Quantity:  

R(+) Lipoic Acid from AOR™ Advanced Orthomolecular Research
Help the body metabolize Carbohydrates*
Dosage: 1 Capsule
Size: 90 Capsules
Category: AOR
Product Number: 08005

Lipoic acid is known as a powerful and versatile antioxidant*

R(+) Lipoic acid is the natural form of this vital antioxidant. It is the sole form produced in the body for use in the mitochondria. Conventional “lipoic acid” supplementst are only 50% R-lipoic acid; the other half of such supplements is the artificial S- enantiomer. Research demonstrates that R -lipoic acid is more potent that the S- form, and that in some cases the S- form interferes with R-lipoic acid’s actions in the body. R-lipoic acid is an antioxidant for the maintenance of good health and helps the body metabolize carbohydrates.*

Lipoic Acid: For Neurological Health and Glucose Metabolism:

If you're taking a conventional lipoic acid pill, then you need to know that the health-promoting, anti-aging benefits associated with this nutrient are only being delivered by half of your supplement. The other half is worse than useless: it actually antagonizes the effects of the good half of the supplement. To put it bluntly: the lipoic acid you're taking harbors both a hero ... and an "evil twin." Many molecules used by the body have a specific "handedness" (chirality). For example, alpha-tocopherol, or essential fatty acids. In some cases, synthetic versions of these molecules have a different "handedness" than the natural molecule. You're probably familiar with some examples of this phenomenon, such as natural d- vs. synthetic dl-alpha-tocopherolor natural cis- vs. unnatural trans-fatty acids. Some of these artificial molecules are merely less potent than the natural forms, such as in the case of dl-alpha-tocopherol. But others are actually harmful - for example, trans-fatty acids

Unless they specify otherwise, "lipoic acid" supplements are a 50/50 mixture of the natural R (+) lipoic acid, and the synthetic S (-) lipoic acid. These mixtures are called "racemates." In some cases, S (-) lipoic acid - or the racemate - is simply less effective than R (+) lipoic acid. But in other cases, the S (-) form actually acts in opposition to the activity of R (+) lipoic acid.

AOR™ guarantees that there is not more than 7mg of S(-)lipoic acid per capsule, and that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, dairy, soy, eggs, fish or shellfish, or any animal byproduct.

Suggested Use:
Take one capsule three times daily with/without food, or as directed by a qualified health care practitioner. Consult a health care practitioner prior to use if you are pregnant or breatfeeding or if you have diabetes.

Main Applications:
As reported by literature:
• Network antioxidant
• Anti-aging
• Cognitive support.
• Neurological function
• Mitochondrial function

Source:
Pharmaceutical synthesis.

Pregnancy / Nursing:
No studies have been conducted. Best to avoid.

Cautions:
Animal experiments suggest that lipoic acid may alter the body's response to levothyroxin (eg. Synthroid®). Consult your physician. Consult a health care practitioner prior to use if you are pregnant or breastfeeding or if you have diabetes.

 Supplement Facts:
 Serving Size: 1 capsule
 Servings per Container: 90


Amount per Serving


% RDI

 R(+) Lipoic Acid (Sodium Salt) 150 mg *
 Sodium 17 mg 0.7%
 Biotin 100 mcg 33%

 % RDI Age 12 and above
 *Need for human nutrition not established
 Other Ingredients: microcrystalline cellulose, sodium stearyl fumarate, silicon dioxide, dicalcium  phosphate. Capsule: hypromellose.

Lipoic Acid: For Neurological Health and Glucose Metabolism

If you're taking a conventional lipoic acid pill, then you need to know that the health-promoting, anti-aging benefits associated with this nutrient are only being delivered by half of your supplement. The other half is worse than useless: it actually antagonizes the effects of the good half of the supplement. To put it bluntly: the lipoic acid you're taking harbors both a hero ... and an "evil twin." Many molecules used by the body have a specific "handedness" (chirality). For example, alpha-tocopherol, or essential fatty acids. In some cases, synthetic versions of these molecules have a different "handedness" than the natural molecule. You're probably familiar with some examples of this phenomenon, such as natural d- vs. synthetic dl-alpha-tocopherolor natural cis- vs. unnatural trans-fatty acids. Some of these artificial molecules are merely less potent than the natural forms, such as in the case of dl-alpha-tocopherol. But others are actually harmful - for example, trans-fatty acids

Unless they specify otherwise, "lipoic acid" supplements are a 50/50 mixture of the natural R(+) lipoic acid, and the synthetic S(-) lipoic acid. These mixtures are called "racemates." In some cases, S(-) lipoic acid - or the racemate - is simply less effective than R(+) lipoic acid. But in other cases, the S(-) form actually acts in opposition to the activity of R(+) lipoic acid.

Glucose Metabolism:
Insulin resistance, in which the cells of the body stop responding properly to the hormone insulin, happens to some degree in almost all of us as we age. Insulin resistance causes higher levels of insulin, blood sugar, and free fatty acids, all of which are threats to your health.

• Lipoic acid has been used to support healthy blood sugar metabolism. Scientists have compared the effects of the two "lipoic acid" molecules seperately.
• R(+) lipoic acid has emerged as the active ingredient in the racemate. R(+) lipoic acid fights all of the major effects of insulin resistance. The S(-) form does not help in some of these areas, and even makes things worse in others.

Antioxidant Defenses:
Lipoic acid is known as a powerful and versatile antioxidant.
• R(+) lipoic acid is more easily absorbed and taken into the cells than S(-) lipoic acid.
• Both forms of lipoic acid can be made more powerful by "charging" them up into their DHLA form. R(+) lipoic acid is "upgraded" much more rapidly than S(-) lipoic acid.
• Many studies have found that R(+) lipoic acid provides much more effective protection than S(-) lipoic acid or the racemate. In some cases, the S(-) lipoic acid actually counteracts the effects of R(+) lipoic acid.

Neurological Health:
Lipoic acid is known for its ability to protect brain and nerve cells from free radicals and toxins. Excessive levels of "transition metals" such as iron, copper, and cadmium are believed to play an important role in many neurological disorders. Having too much free iron in a key part of the brain has been implicated as a cause of Parkinson's disease, for example.

• R(+) lipoic acid supplements partially reverse the age-associated loss of spatial and temporal memory seen in old animals.
• An animal study using R(+) lipoic acid found that it was able to significantly reduce age-related buildup of iron in the brain. Other studies suggest that S(-) lipoic acid will not work as well.

Mitochondrial Function
The biggest source of free radicals in your body are your cellular "power plants," the mitochondria. They are both the origin, and the target, of most of the free radical damage in the body. As we age, our mitochondria become less and less efficient, generating less and less energy while creating more and more free radicals.

• R(+) lipoic acid, in animal experiments and in test-tube studies, makes mitochondria more efficient, so that they produce more energy and create fewer free radicals. Age-associated damage to mitochondrial structure is significantly reduced. S(-) lipoic acid does not have these effects, and may antagonize the action of R(+) lipoic acid.
• These benefits have a real impact on the organism. Animals undergoing a simulated heart attack recover heart function more rapidly when infused with R(+) lipoic acid; S(-) lipoic acid has no such effect.
• Animals who receive R(+) lipoic acid supplements look better and are more active.

Fundamental Aging:
Nearly all researchers into the biology of aging agree that the decay of mitochondrial function is a major engine of the aging process. Caloric restriction, with adequate nutrition, is the only proven way to slow down the fundamental aging process in mammals.

• Many of the benefits of R(+) lipoic acid closely mimic those of caloric restriction. R(+) lipoic acid's effects on mitochondrial function are the most striking and unique parallel.
• A study in a short-lived strain of mouse demonstrated that R(+) lipoic acid can dramatically increase its lifespan. Neither S(-) lipoic acid, nor the racemate, had any significant effect.
• The National Institutes on Aging are currently funding studies to see if R(+) lipoic acid can truly slow down the aging process.

The Bottom Line
• Common "lipoic acid" supplements are thus like a house at war with itself. The S(-) form should be removed from supplements in favor of pure R(+) lipoic acid.

"We're finding - and others are, too - that the R(+) form - the natural form - is much more powerful than the racemic mixture ... Hopefully ... companies are going to be producing on more of a clinical scale the R(+) form of lipoic acid, because we're finding very significant effects using this, as opposed to the racemic mixture." - Dr. Tory Hagen, in Mitochondrial Decay in Aging.

"We have presented in this study new information indicating that this enhancement of glucose metabolism is sterospecific, with the R(+) enantiomer being much more effective than the S(-) enantiomer." - Dr. Ryan Streeper and colleagues, in The American Journal of Physiology.

"Lipoic acid sold in a health food store is a synthetic mixture, a racemic mixture. And R(+) is the natural form and S(-) is an unnatural one ... And in our hands R(+) works and S (-) doesn't." - Dr. Bruce Ames, in Strategies for Engineered Negligible Senescence.

"R(+) LA [that is, R(+) lipoic acid], and not a racemic mixture of R(+) and S(-) LA, should be considered a choice for therapeutic applications." - Dr. Lester Packer and colleagues, in Free Radical Biology and Medicine.

"The S(-) enantiomer ... part of the racemate, which is present as about a 50% impurity, needs to be eliminated." - Dr. Guido Zimmer and colleagues, in Methods in Enzymology.

References:

i. Streeper RS, Henriksen EJ, Jacob S, Hokama JY, Fogt DL, Tritschler HJ. "Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle." Am J Physiol. 1997 Jul; 273(1 Pt 1): E185-91.

ii. Hagen TM, Vinarsky V, Wehr CM, Ames BN. "(R)-alpha-lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo." Antioxid Redox Signal. 2000 Fall; 2(3): 473-83.

iii. Lockhart B, Jones C, Cuisinier C, Villain N, Peyroulan D, Lestage P. "Inhibition of L-homocysteic acid and buthionine sulphoximine-mediated neurotoxicity in rat embryonic neuronal cultures with alpha-lipoic acid enantiomers." Brain Res. 2000 Feb 14; 855(2): 292-7.

iv. Suh J, Rocha A, Shigeno E, Frei B, Hagen TM. "(R)-alpha-lipoic acid supplementation of old rats decreases age-dependent accumulation of iron and ascorbate depletion in brain." AGE. 1999 Jul; 22(3): 121(Abs 19).

v. Hagen TM, Ingersoll RT, Lykkesfeldt J, Liu J, Wehr CM, Vinarsky V, Bartholomew JC, Ames AB. "(R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate." FASEB J. 1999 Feb; 13(2): 411-8.


The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide medical advice to individuals. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes. Any reproduction in whole or part and in print or electronic form without express permission is strictly forbidden. Permission to reproduce selected material may be granted by contacting AOR Inc.

Copyright © 2011, Advanced Orthomolecular Research

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.